Gilbert's syndrome

Gilbert’s Syndrome is an inherited condition, first described in 1901 by French gastroenterologist Augustin Nicolas Gilbert and found in approx 5 - 10% of the population. It is the most common hereditary cause of increased levels of bilirubin, a yellowish pigment normally found in small amounts in blood and urine.

Gilbert’s Syndrome is caused by changes in the DNA sequence of the gene called UGT1A1, the gene that produces an enzyme that helps the body clear bilirubin from the body.

Symptoms

The main symptoms of this otherwise harmless condition is a mild jaundice (yellowing) of the skin and eyes which is ususually mild and requires no treatment.  Certain activities, such as missing meals, lack of sleep, vigorous exercise, illness and stress, may make these symptoms worse, by placing further stress upon the liver.